CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection

The co-stimulatory molecule CD28 is essential for activation of helper T cells. Despite this critical role, it is not known whether CD28 has functions in maintaining T cell responses following activation. To determine the role for CD28 after T cell priming, we generated a strain of mice where CD28 i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Linterman, Michelle A, Denton, Alice E, Divekar, Devina P, Zvetkova, Ilona, Kane, Leanne, Ferreira, Cristina, Veldhoen, Marc, Clare, Simon, Dougan, Gordon, Espéli, Marion, Smith, Kenneth GC
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241536/
https://ncbi.nlm.nih.gov/pubmed/25347065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03180
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