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Copper Directs ATP7B to the Apical Domain of Hepatic Cells via Basolateral Endosomes

Physiologic Cu levels regulate the intracellular location of the Cu ATPase ATP7B. Here, we determined the routes of Cu-directed trafficking of endogenous ATP7B in the polarized hepatic cell line WIF-B and in the liver in vivo. Copper (10 μM) caused ATP7B to exit the trans-Golgi network (TGN) in vesi...

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發表在:Traffic
Main Authors: Nyasae, Lydia K., Schell, Michael J., Hubbard, Ann L.
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241365/
https://ncbi.nlm.nih.gov/pubmed/25243755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12229
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