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Vps34p differentially regulates endocytosis from the apical and basolateral domains in polarized hepatic cells

Using a microinjection approach to study apical plasma membrane protein trafficking in hepatic cells, we found that specific inhibition of Vps34p, a class III phosphoinositide 3 (PI-3) kinase, nearly perfectly recapitulated the defects we reported for wortmannin-treated cells (Tuma, P.L., C.M. Finne...

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Detalhes bibliográficos
Main Authors: Tuma, Pamela L., Nyasae, Lydia K., Backer, Jonathan M., Hubbard, Ann L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150819/
https://ncbi.nlm.nih.gov/pubmed/11564757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200105138
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