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Copper Directs ATP7B to the Apical Domain of Hepatic Cells via Basolateral Endosomes
Physiologic Cu levels regulate the intracellular location of the Cu ATPase ATP7B. Here, we determined the routes of Cu-directed trafficking of endogenous ATP7B in the polarized hepatic cell line WIF-B and in the liver in vivo. Copper (10 μM) caused ATP7B to exit the trans-Golgi network (TGN) in vesi...
Shranjeno v:
| izdano v: | Traffic |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4241365/ https://ncbi.nlm.nih.gov/pubmed/25243755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12229 |
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