Synaptic plasticity mediating cocaine relapse requires matrix metalloproteinases

Relapse to cocaine use necessitates remodeling excitatory synapses in the nucleus accumbens, and synaptic reorganization requires matrix metalloproteinase (MMP) degradation of the extracellular matrix proteins. We found enduring increases in MMP-2 activity in rats after withdrawal from self-administ...

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Publicado en:Nat Neurosci
Autores principales: Smith, Alexander C. W., Kupchik, Yonatan M., Scofield, Michael D., Gipson, Cassandra D., Wiggins, Armina, Kalivas, Peter W.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241163/
https://ncbi.nlm.nih.gov/pubmed/25326689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.3846
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