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Late, never or non-existent: the inaccessibility of preclinical evidence for new drugs

BACKGROUND AND PURPOSE: Animal studies establish much of the evidence used to support clinical development of new drugs. Recent studies suggest that many preclinical investigations are withheld from publication, leading to exaggerated estimates of clinical utility. We sought to estimate the volume a...

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Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Federico, C A, Carlisle, B, Kimmelman, J, Fergusson, D A
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4241091/
https://ncbi.nlm.nih.gov/pubmed/24825131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12771
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