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Enhanced aggressiveness of benzopyrene-induced squamous carcinomas in transgenic mice overexpressing the proprotein convertase PACE4 (PCSK6)

PACE4 (PCSK6) is a pro-protein convertase (PC) capable of processing numerous substrates involved in tumor growth, invasion, and metastasis. Because of the human relevancy of the tobacco-associated carcinogen benzo[a]pyrene (B(a)P) we investigated whether transgenic mice in which this PC is targeted...

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Udgivet i:Mol Carcinog
Main Authors: Bassi, Daniel E., Cenna, Jonathan, Zhang, Jirong, Cukierman, Edna, Klein-Szanto, Andres J.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4240754/
https://ncbi.nlm.nih.gov/pubmed/24845697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22183
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