Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records

AIMS: HMG-CoA reductase inhibitors are available for use in low density lipoprotein-cholesterol (LDL-C) lowering therapy. The purposes of this study were to develop a population pharmacodynamic (PPD) model to describe the time course for the LDL-C lowering effects of statins and assess the efficacy...

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Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Kakara, Makoto, Nomura, Hiroko, Fukae, Masato, Gotanda, Keisuke, Hirota, Takeshi, Matsubayashi, Sunao, Shimomura, Hideki, Hirakawa, Masaaki, Ieiri, Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2014
Témata:
Pharmacodynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239976/
https://ncbi.nlm.nih.gov/pubmed/24734885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12405
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