KRIT1 Protein Depletion Modifies Endothelial Cell Behavior via Increased Vascular Endothelial Growth Factor (VEGF) Signaling

Disruption of endothelial cell-cell contact is a key event in many cardiovascular diseases and a characteristic of pathologically activated vascular endothelium. The CCM (cerebral cavernous malformation) family of proteins (KRIT1 (Krev-interaction trapped 1), PDCD10, and CCM2) are critical regulator...

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Udgivet i:J Biol Chem
Main Authors: DiStefano, Peter V., Kuebel, Julia M., Sarelius, Ingrid H., Glading, Angela J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2014
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239650/
https://ncbi.nlm.nih.gov/pubmed/25320085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.582304
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