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The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation
Lysosome rupture triggers NLRP3 inflammasome activation in macrophages. However, the underlying mechanism is not fully understood. Here we showed that the TAK1-JNK pathway, a MAPK signaling pathway, is activated through lysosome rupture and that this activation is necessary for the complete activati...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4239639/ https://ncbi.nlm.nih.gov/pubmed/25288801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.579961 |
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