Biochemical Characterization of Pathogenic Mutations in Human Mitochondrial Methionyl-tRNA Formyltransferase

N-Formylation of initiator methionyl-tRNA (Met-tRNA(Met)) by methionyl-tRNA formyltransferase (MTF) is important for translation initiation in bacteria, mitochondria, and chloroplasts. Unlike all other translation systems, the metazoan mitochondrial system is unique in using a single methionine tRNA...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Sinha, Akesh, Köhrer, Caroline, Weber, Michael H. W., Masuda, Isao, Mootha, Vamsi K., Hou, Ya-Ming, RajBhandary, Uttam L.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239624/
https://ncbi.nlm.nih.gov/pubmed/25288793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.610626
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