67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance

The Ras/Raf/MEK/ERK pathway has been identified as a major, druggable regulator of melanoma. Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, resulting in constitutive melanoma hyperproliferation. A selective BRAF inhibitor showed remarkable clinical activity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Tsukamoto, Shuntaro, Huang, Yuhui, Umeda, Daisuke, Yamada, Shuhei, Yamashita, Shuya, Kumazoe, Motofumi, Kim, Yoonhee, Murata, Motoki, Yamada, Koji, Tachibana, Hirofumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2014
Pynciau:
Molecular Bases of Disease
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239619/
https://ncbi.nlm.nih.gov/pubmed/25294877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604983
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