67-kDa Laminin Receptor-dependent Protein Phosphatase 2A (PP2A) Activation Elicits Melanoma-specific Antitumor Activity Overcoming Drug Resistance

The Ras/Raf/MEK/ERK pathway has been identified as a major, druggable regulator of melanoma. Mutational activation of BRAF is the most prevalent genetic alteration in human melanoma, resulting in constitutive melanoma hyperproliferation. A selective BRAF inhibitor showed remarkable clinical activity...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Tsukamoto, Shuntaro, Huang, Yuhui, Umeda, Daisuke, Yamada, Shuhei, Yamashita, Shuya, Kumazoe, Motofumi, Kim, Yoonhee, Murata, Motoki, Yamada, Koji, Tachibana, Hirofumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239619/
https://ncbi.nlm.nih.gov/pubmed/25294877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.604983
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