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High-fat diet-induced changes in liver thioredoxin and thioredoxin reductase as a novel feature of insulin resistance

High-fat diet (HFD) can induce oxidative stress. Thioredoxin (Trx) and thioredoxin reductase (TrxR) are critical antioxidant proteins but how they are affected by HFD remains unclear. Using HFD-induced insulin-resistant mouse model, we show here that liver Trx and TrxR are significantly decreased, b...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Qin, Huijun, Zhang, Xiaolin, Ye, Fei, Zhong, Liangwei
Format: Artigo
Language:Inglês
Published: Elsevier 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239481/
https://ncbi.nlm.nih.gov/pubmed/25426412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.10.015
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