Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3

Severe sepsis and septic shock are leading causes of morbidity and mortality worldwide. Infection-associated inflammation promotes the development and progression of adverse outcomes in sepsis. The effects of heterodimeric Interleukin-27 (IL-27; p28/EBI3) have been implicated in the natural course o...

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Pubblicato in:J Immunol
Autori principali: Bosmann, Markus, Russkamp, Norman F., Strobl, Birgit, Roewe, Julian, Balouzian, Liza, Pache, Florence, Radsak, Markus P., van Rooijen, Nico, Zetoune, Firas S., Sarma, J. Vidya, Núñez, Gabriel, Müller, Mathias, Murray, Peter J., Ward, Peter A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4239188/
https://ncbi.nlm.nih.gov/pubmed/25348624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302280
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