Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

Enteropathogenic E. coli (EPEC) and related enterobacteria rely on a type III secretion system (T3SS) effector NleE to block host NF-κB signaling. NleE is a first in class, novel S-adenosyl-L-methionine (SAM)-dependent methyltransferase that methylates a zinc-coordinating cysteine in the Npl4-like Z...

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Bibliographic Details
Published in:	PLoS Pathog
Main Authors:	Yao, Qing, Zhang, Li, Wan, Xiaobo, Chen, Jing, Hu, Liyan, Ding, Xiaojun, Li, Lin, Karar, Jayashree, Peng, Hongzhuang, Chen, She, Huang, Niu, Rauscher, Frank J., Shao, Feng
Format:	Artigo
Language:	Inglês
Published:	Public Library of Science 2014
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4239114/ https://ncbi.nlm.nih.gov/pubmed/25412445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004522
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Structure and Specificity of the Bacterial Cysteine Methyltransferase Effector NleE Suggests a Novel Substrate in Human DNA Repair Pathway

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