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Bacterial sensor Nod2 prevents small intestinal inflammation by restricting the expansion of the commensal Bacteroides vulgatus

Nod2 has been extensively characterized as a bacterial sensor that induces an antimicrobial and inflammatory gene expression program. Therefore, it is unclear why Nod2 mutations that disrupt bacterial recognition are paradoxically among the highest risk factors for Crohn’s disease, which involves an...

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Detalles Bibliográficos
Publicado en:Immunity
Main Authors: Ramanan, Deepshika, Tang, Mei San, Bowcutt, Rowann, Loke, P’ng, Cadwell, Ken
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238935/
https://ncbi.nlm.nih.gov/pubmed/25088769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.015
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