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Bacterial sensor Nod2 prevents small intestinal inflammation by restricting the expansion of the commensal Bacteroides vulgatus
Nod2 has been extensively characterized as a bacterial sensor that induces an antimicrobial and inflammatory gene expression program. Therefore, it is unclear why Nod2 mutations that disrupt bacterial recognition are paradoxically among the highest risk factors for Crohn’s disease, which involves an...
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| Publié dans: | Immunity |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4238935/ https://ncbi.nlm.nih.gov/pubmed/25088769 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2014.06.015 |
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