Drug discovery for Chagas disease should consider Trypanosoma cruzi strain diversity

This opinion piece presents an approach to standardisation of an important aspect of Chagas disease drug discovery and development: selecting Trypanosoma cruzi strains for in vitro screening. We discuss the rationale for strain selection representing T. cruzi diversity and provide recommendations on...

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Publicat a:Mem Inst Oswaldo Cruz
Autors principals: Zingales, Bianca, Miles, Michael A, Moraes, Carolina B, Luquetti, Alejandro, Guhl, Felipe, Schijman, Alejandro G, Ribeiro, Isabela
Format: Artigo
Idioma:Inglês
Publicat: Instituto Oswaldo Cruz, Ministério da Saúde 2014
Matèries:
Readers' Opinion
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238778/
https://ncbi.nlm.nih.gov/pubmed/25317712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-0276140156
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