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Total synthesis of (±)-leuconolam: intramolecular allylic silane addition to a maleimide carbonyl group
A concise total synthesis of the plant alkaloid (±)-leuconolam (1) has been achieved. A regio- and diastereoselective Lewis-acid mediated allylative cyclization was used to establish, simultaneously, two adjacent tetrasubstituted carbon centers. Furthermore, an essential arene cross-coupling to a hi...
Enregistré dans:
| Publié dans: | Chem Sci |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4238231/ https://ncbi.nlm.nih.gov/pubmed/25419448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3SC00056G |
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