Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer

Utilizing molecular data to derive functional physiological models tailored for specific cancer cells can facilitate the use of individually tailored therapies. To this end we present an approach termed PRIME for generating cell-specific genome-scale metabolic models (GSMMs) based on molecular and p...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Yizhak, Keren, Gaude, Edoardo, Le Dévédec, Sylvia, Waldman, Yedael Y, Stein, Gideon Y, van de Water, Bob, Frezza, Christian, Ruppin, Eytan
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238051/
https://ncbi.nlm.nih.gov/pubmed/25415239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03641
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