SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

BACKGROUND: Dominant mutations in superoxide dismutase 1 (SOD1) cause degeneration of motor neurons in a subset of inherited amyotrophic lateral sclerosis (ALS). The pathogenetic process mediated by misfolded and/or aggregated mutant SOD1 polypeptides is hypothesized to be suppressed by protein refo...

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Bibliografiske detaljer
Udgivet i:Mol Brain
Main Authors: Watanabe, Seiji, Ageta-Ishihara, Natsumi, Nagatsu, Shinji, Takao, Keizo, Komine, Okiru, Endo, Fumito, Miyakawa, Tsuyoshi, Misawa, Hidemi, Takahashi, Ryosuke, Kinoshita, Makoto, Yamanaka, Koji
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237944/
https://ncbi.nlm.nih.gov/pubmed/25167838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-014-0062-1
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