A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice

BACKGROUND: Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic...

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Publicat a:Mol Cancer
Autors principals: Rosemann, Michael, Gonzalez-Vasconcellos, Iria, Domke, Tanja, Kuosaite, Virginija, Schneider, Ralf, Kremer, Markus, Favor, Jack, Nathrath, Michaela, Atkinson, Michael J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237942/
https://ncbi.nlm.nih.gov/pubmed/25092376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-182
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