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A Rb1 promoter variant with reduced activity contributes to osteosarcoma susceptibility in irradiated mice
BACKGROUND: Syndromic forms of osteosarcoma (OS) account for less than 10% of all recorded cases of this malignancy. An individual OS predisposition is also possible by the inheritance of low penetrance alleles of tumor susceptibility genes, usually without evidence of a syndromic condition. Genetic...
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Publicado no: | Mol Cancer |
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Main Authors: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BioMed Central
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4237942/ https://ncbi.nlm.nih.gov/pubmed/25092376 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-182 |
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