Small-molecule survivin inhibitor YM155 enhances radiosensitization in esophageal squamous cell carcinoma by the abrogation of G(2) checkpoint and suppression of homologous recombination repair

BACKGROUND: Survivin is overexpressed in cancer cells and plays a crucial role in apoptosis evasion. YM155, a small-molecule inhibitor of survivin, could enhance the cytotoxicity of various DNA-damaging agents. Here, we evaluated the radiosensitizaion potential of YM155 in human esophageal squamous...

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Veröffentlicht in:J Hematol Oncol
Hauptverfasser: Qin, Qin, Cheng, Hongyan, Lu, Jing, Zhan, Liangliang, Zheng, Jianchao, Cai, Jing, Yang, Xi, Xu, Liping, Zhu, Hongcheng, Zhang, Chi, Liu, Jia, Ma, Jianxin, Zhang, Xizhi, Dai, Shengbin, Sun, Xinchen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237864/
https://ncbi.nlm.nih.gov/pubmed/25139395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-014-0062-8
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