Divalent cation regulation of the surface orientation of platelet membrane glycoprotein IIb. Correlation with fibrinogen binding function and definition of a novel variant of Glanzmann's thrombasthenia.

An antiplatelet monoclonal antibody, PMI-1, reacts with glycoproteins (GP) GPIIb, free GPIIb, and the GPIIb-IIIa complex. This antibody binds to 40,900 sites per platelet, with a Kd = 0.95 microM, and its binding is inhibited by the presence of magnesium or calcium in the suspending medium (50% supp...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Ginsberg, M H, Lightsey, A, Kunicki, T J, Kaufmann, A, Marguerie, G, Plow, E F
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1986
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423772/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2428841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112667
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