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Pyrazine-Derived Disulfide-Reducing Agent for Chemical Biology

For fifty years, dithiothreitol (DTT) has been the preferred reagent for the reduction of disulfide bonds in proteins and other biomolecules. Herein we report on the synthesis and characterization of 2,3-bis(mercaptomethyl)pyrazine (BMMP), a readily accessible disulfide-reducing agent with reactivit...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Commun (Camb)
Main Authors: Lukesh, John C., Wallin, Kelly K., Raines, Ronald T.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237594/
https://ncbi.nlm.nih.gov/pubmed/25014913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4cc04491f
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