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Validation of 6-Minute Walk Distance as a Surrogate End Point in Pulmonary Arterial Hypertension Trials

BACKGROUND: Nearly all available treatments for pulmonary arterial hypertension have been approved based on change in 6-minute walk distance (Δ6MWD) as a clinically important end point, but its validity as a surrogate end point has never been shown. We aimed to validate the difference in Δ6MWD again...

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Foilsithe in:Circulation
Main Authors: Gabler, Nicole B., French, Benjamin, Strom, Brian L., Palevsky, Harold I., Taichman, Darren B., Kawut, Steven M., Halpern, Scott D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237273/
https://ncbi.nlm.nih.gov/pubmed/22696079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.105890
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