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Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway

Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent with cancer cell-selective cell death inducing effect. However, the major limitation in the usage of TRAIL as a chemotherapeutic agent is the development of TRAIL resistance in many cancer types includi...

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Foilsithe in:Cell Death Dis
Main Authors: Trivedi, R, Maurya, R, Mishra, D P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2014
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237253/
https://ncbi.nlm.nih.gov/pubmed/25321472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.429
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