Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive product cleaved at the NH2 terminus.

The effect of plasma on degradation of human growth hormone-releasing hormone (GRH) was examined in vitro and in vivo using high performance liquid chromatography (HPLC), radioimmunoassay (RIA), and bioassay. When GRH(1-44)-NH2 was incubated with human plasma, the t1/2 of total GRH immunoreactivity...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Frohman, L A, Downs, T R, Williams, T C, Heimer, E P, Pan, Y C, Felix, A M
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 1986
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423714/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3093533/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112679
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