Dipeptidylpeptidase IV and trypsin-like enzymatic degradation of human growth hormone-releasing hormone in plasma.

The plasma enzyme responsible for primary proteolytic cleavage of growth hormone-releasing hormone (GRH) at the 2-3 amino acid bond was characterized. Native GRH[GRH(1-44)-NH2 and GRH(1-40)-OH], and COOH-terminally shortened fragments [GRH(1-32)-NH2 and GRH(1-29)-NH2] were rapidly cleaved, while GRH...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Frohman, L A, Downs, T R, Heimer, E P, Felix, A M
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC303858/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2565342/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI114049
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