Recombinant human transforming growth factor-alpha stimulates the formation of osteoclast-like cells in long-term human marrow cultures.

Transforming growth factor-alpha (TGF-alpha) is synthesized by a variety of tumor cell lines and stimulates osteoclastic bone resorption in vitro. The mechanism by which TGF-alpha increases osteoclast activity is unknown. We used a human marrow culture system that forms osteoclast-like multinucleate...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Takahashi, N, MacDonald, B R, Hon, J, Winkler, M E, Derynck, R, Mundy, G R, Roodman, G D
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423711/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3489738/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112677
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