Mutation of Murine Sox4 Untranslated Regions Results in Partially Penetrant Perinatal Lethality

BACKGROUND: Sox4 is an essential gene, and genetic deletion results in embryonic lethality. In an effort to develop mice with tissue-specific deletion, we bred conditional knockout mice bearing LoxP recombination sites flanking the Sox4 gene, with the LoxP sites located in the Sox4 5’UTR and 3’UTR....

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Publicat a:In Vivo
Autors principals: Wiles, Walter Guy, Mou, Zhongming, Du, Yang, Long, Alyssa B., Scharer, Christopher D., Bilir, Birdal, Spyropoulos, Demetri D., Jenkins, Nancy A., Copeland, Neal G., Martin, W. David, Moreno, Carlos S.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237010/
https://ncbi.nlm.nih.gov/pubmed/25189881
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