Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

INTRODUCTION: Previous magnetic resonance spectroscopy (MRS) and mass spectroscopy studies have shown accumulation of 2-hydroxyglutarate (2HG) in mutant isocitrate dehydrogenase (IDH) gliomas. IDH mutation is known to be a powerful positive prognostic marker in malignant gliomas. Hence, 2HG accumula...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Natsumeda, Manabu, Igarashi, Hironaka, Nomura, Toshiharu, Ogura, Ryosuke, Tsukamoto, Yoshihiro, Kobayashi, Tsutomu, Aoki, Hiroshi, Okamoto, Kouichirou, Kakita, Akiyoshi, Takahashi, Hitoshi, Nakada, Tsutomu, Fujii, Yukihiko
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236810/
https://ncbi.nlm.nih.gov/pubmed/25376594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-014-0158-y
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