Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle a...

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Vydáno v:Sci Rep
Hlavní autoři: Arimura, Yasuhiro, Shirayama, Kazuyoshi, Horikoshi, Naoki, Fujita, Risa, Taguchi, Hiroyuki, Kagawa, Wataru, Fukagawa, Tatsuo, Almouzni, Geneviève, Kurumizaka, Hitoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236741/
https://ncbi.nlm.nih.gov/pubmed/25408271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07115
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