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Crystal structure and stable property of the cancer-associated heterotypic nucleosome containing CENP-A and H3.3

The centromere-specific histone H3 variant, CENP-A, is overexpressed in particular aggressive cancer cells, where it can be mislocalized ectopically in the form of heterotypic nucleosomes containing H3.3. In the present study, we report the crystal structure of the heterotypic CENP-A/H3.3 particle a...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Arimura, Yasuhiro, Shirayama, Kazuyoshi, Horikoshi, Naoki, Fujita, Risa, Taguchi, Hiroyuki, Kagawa, Wataru, Fukagawa, Tatsuo, Almouzni, Geneviève, Kurumizaka, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236741/
https://ncbi.nlm.nih.gov/pubmed/25408271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07115
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