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Analysis of the quantitative balance between insulin-like growth factor (IGF)-1 ligand, receptor, and binding protein levels to predict cell sensitivity and therapeutic efficacy

BACKGROUND: The insulin-like growth factor (IGF) system impacts cell proliferation and is highly activated in ovarian cancer. While an attractive therapeutic target, the IGF system is complex with two receptors (IGF1R, IGF2R), two ligands (IGF1, IGF2), and at least six high affinity IGF-binding prot...

詳細記述

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書誌詳細
出版年:BMC Syst Biol
主要な著者: Tian, Dan, Kreeger, Pamela K
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236724/
https://ncbi.nlm.nih.gov/pubmed/25115504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-014-0098-y
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