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Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities.

The study of the Ig variable region heavy chain (VH) genes used to encode antibodies specific for self-epitopes from murine hybridomas showed that three VH families are primarily utilized: VH J558, the largest family, and VH QPC52 and VH 7183, the families most proximal to the Ig joining region heav...

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Udgivet i:J Clin Invest
Principais autores: Monestier, M, Manheimer-Lory, A, Bellon, B, Painter, C, Dang, H, Talal, N, Zanetti, M, Schwartz, R, Pisetsky, D, Kuppers, R
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 1986
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423668/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2427543/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112637
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