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Moving beyond anti-amyloid therapy for the prevention and treatment of Alzheimer’s disease

BACKGROUND: High-profile Phase 3 clinical trials of bapineuzumab and solanezumab, antibodies targeted at amyloid-beta (Aβ) removal, have failed to meet their primary endpoints. Neither drug improves clinical outcomes in patients with late onset AD, joining a long list of unsuccessful attempts to tre...

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Detalhes bibliográficos
Publicado no:BMC Neurol
Main Authors: Castello, Michael A, Jeppson, John David, Soriano, Salvador
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236650/
https://ncbi.nlm.nih.gov/pubmed/25179671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12883-014-0169-0
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