Dual effects of a targeted small-molecule inhibitor (cabozantinib) on immune-mediated killing of tumor cells and immune tumor microenvironment permissiveness when combined with a cancer vaccine

BACKGROUND: Growing awareness of the complexity of carcinogenesis has made multimodal therapies for cancer increasingly compelling and relevant. In recent years, immunotherapy has gained acceptance as an active therapeutic approach to cancer treatment, even though cancer is widely considered an immu...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Transl Med
Auteurs principaux: Kwilas, Anna R, Ardiani, Andressa, Donahue, Renee N, Aftab, Dana T, Hodge, James W
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2014
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236498/
https://ncbi.nlm.nih.gov/pubmed/25388653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0294-y
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