Aberrant α-Adrenergic Hypertrophic Response in Cardiomyocytes from Human Induced Pluripotent Cells

Cardiomyocytes from human embryonic stem cells (hESC-CMs) and induced pluripotent stem cells (hiPSC-CMs) represent new models for drug discovery. Although hypertrophy is a high-priority target, we found that hiPSC-CMs were systematically unresponsive to hypertrophic signals such as the α-adrenocepto...

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Pubblicato in:Stem Cell Reports
Autori principali: Földes, Gabor, Matsa, Elena, Kriston-Vizi, János, Leja, Thomas, Amisten, Stefan, Kolker, Ljudmila, Kodagoda, Thusharika, Dolatshad, Nazanin F., Mioulane, Maxime, Vauchez, Karine, Arányi, Tamás, Ketteler, Robin, Schneider, Michael D., Denning, Chris, Harding, Sian E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235744/
https://ncbi.nlm.nih.gov/pubmed/25418732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2014.09.002
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