Enhanced HIV-1 immunotherapy by commonly arising antibodies that target virus escape variants

Antibody-mediated immunotherapy is effective in humanized mice when combinations of broadly neutralizing antibodies (bNAbs) are used that target nonoverlapping sites on the human immunodeficiency virus type 1 (HIV-1) envelope. In contrast, single bNAbs can control simian–human immunodeficiency virus...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Klein, Florian, Nogueira, Lilian, Nishimura, Yoshiaki, Phad, Ganesh, West, Anthony P., Halper-Stromberg, Ariel, Horwitz, Joshua A., Gazumyan, Anna, Liu, Cassie, Eisenreich, Thomas R., Lehmann, Clara, Fätkenheuer, Gerd, Williams, Constance, Shingai, Masashi, Martin, Malcolm A., Bjorkman, Pamela J., Seaman, Michael S., Zolla-Pazner, Susan, Karlsson Hedestam, Gunilla B., Nussenzweig, Michel C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
Subjects:
Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235636/
https://ncbi.nlm.nih.gov/pubmed/25385756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141050
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