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Enantioselective CuH-Catalyzed Anti-Markovnikov Hydroamination of 1,1-Disubstituted Alkenes

[Image: see text] Enantioselective synthesis of β-chiral amines has been achieved via copper-catalyzed hydroamination of 1,1-disubstituted alkenes with hydroxylamine esters in the presence of a hydrosilane. This mild process affords a range of structurally diverse β-chiral amines, including β-deuter...

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Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Zhu, Shaolin, Buchwald, Stephen L.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2014
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235366/
https://ncbi.nlm.nih.gov/pubmed/25339089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja509786v
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