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5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.
The effect of 5-azacytidine on erythroid precursors and progenitors was studied in nine patients with sickle cell anemia or severe thalassemia. Each patient received the drug intravenously for 5 or 7 d. 5-Azacytidine caused a four- to sixfold increase in gamma-messenger RNA concentration in bone mar...
Tallennettuna:
| Julkaisussa: | J Clin Invest |
|---|---|
| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Clinical Investigation
1985
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423530/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2579100/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111731 |
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