5-Azacytidine acts directly on both erythroid precursors and progenitors to increase production of fetal hemoglobin.

The effect of 5-azacytidine on erythroid precursors and progenitors was studied in nine patients with sickle cell anemia or severe thalassemia. Each patient received the drug intravenously for 5 or 7 d. 5-Azacytidine caused a four- to sixfold increase in gamma-messenger RNA concentration in bone mar...

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Detalhes bibliográficos
Main Authors: Humphries, R K, Dover, G, Young, N S, Moore, J G, Charache, S, Ley, T, Nienhuis, A W
Formato: Artigo
Idioma:Inglês
Publicado em: 1985
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC423530/
https://ncbi.nlm.nih.gov/pubmed/2579100
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