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Leptin induced GRP78 expression through the PI3K-mTOR pathway in neuronal cells

Leptin is a circulating hormone that plays a critical role in regulating energy expenditure and food intake. Evidence to suggest the involvement of endoplasmic reticulum (ER) stress in the development of obesity is increasing. To adapt against ER stress, cells trigger the unfolded protein response (...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Thon, Mina, Hosoi, Toru, Yoshii, Michiko, Ozawa, Koichiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235288/
https://ncbi.nlm.nih.gov/pubmed/25403445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07096
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