Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain

OBJECTIVE: HIV-associated neurocognitive deficits remain a challenge despite suppressive combined antiretroviral therapy. Given the association between HIV-induced central nervous system (CNS) disease and replication of HIV in immune-activated macrophages, CCR5 antagonists may attenuate CNS disease...

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Published in:AIDS
Main Authors: Kelly, Kathleen M., Beck, Sarah E., Pate, Kelly A. Metcalf, Queen, Suzanne E., Dorsey, Jamie L., Adams, Robert J., Avery, Lindsay B., Hubbard, Walter, Tarwater, Patrick M., Mankowski, Joseph L.
Format: Artigo
Language:Inglês
Published: Lippincott Williams & Wilkins 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235167/
https://ncbi.nlm.nih.gov/pubmed/24051706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0000000000000074
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