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Neuromyelitis optica pathology in rats following intraperitoneal injection of NMO-IgG and intracerebral needle injury

INTRODUCTION: Animal models of neuromyelitis optica (NMO) are needed for drug testing and evaluation of NMO disease pathogenesis mechanisms. RESULTS: We describe a novel passive-transfer model of NMO in which rats made seropositive for human anti-aquaporin-4 (AQP4) immunoglobulin G antibody (NMO-IgG...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Asavapanumas, Nithi, Verkman, AS
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234989/
https://ncbi.nlm.nih.gov/pubmed/24758159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-5960-2-48
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