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How Does Domain Replacement Affect Fibril Formation of the Rabbit/Human Prion Proteins

BACKGROUND: It is known that in vivo human prion protein (PrP) have the tendency to form fibril deposits and are associated with infectious fatal prion diseases, while the rabbit PrP does not readily form fibrils and is unlikely to cause prion diseases. Although we have previously demonstrated that...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Yan, Xu, Huang, Jun-Jie, Zhou, Zheng, Chen, Jie, Liang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234653/
https://ncbi.nlm.nih.gov/pubmed/25401497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113238
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