The AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes

Centromeres mediate chromosome segregation and are defined by the centromere-specific histone H3 variant (CenH3)/centromere protein A (CENP-A). Removal of CenH3 from centromeres is a general property of terminally differentiated cells, and the persistence of CenH3 increases the risk of diseases such...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Mérai, Zsuzsanna, Chumak, Nina, García-Aguilar, Marcelina, Hsieh, Tzung-Fu, Nishimura, Toshiro, Schoft, Vera K., Bindics, János, Ślusarz, Lucyna, Arnoux, Stéphanie, Opravil, Susanne, Mechtler, Karl, Zilberman, Daniel, Fischer, Robert L., Tamaru, Hisashi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2014
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234600/
https://ncbi.nlm.nih.gov/pubmed/25344531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418564111
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