Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells.

We have previously reported that the normal membrane phospholipid organization is altered in sickled erythrocytes. More recently, we presented evidence of enhanced transbilayer movement of phosphatidylcholine (PC) in deoxygenated reversibly sickled cells (RSC) and put forward the hypothesis that the...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Franck, P F, Bevers, E M, Lubin, B H, Comfurius, P, Chiu, D T, Op den Kamp, J A, Zwaal, R F, van Deenen, L L, Roelofsen, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1985
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423425/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3965502/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111672
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