Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells.

We have previously reported that the normal membrane phospholipid organization is altered in sickled erythrocytes. More recently, we presented evidence of enhanced transbilayer movement of phosphatidylcholine (PC) in deoxygenated reversibly sickled cells (RSC) and put forward the hypothesis that the...

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Main Authors: Franck, P F, Bevers, E M, Lubin, B H, Comfurius, P, Chiu, D T, Op den Kamp, J A, Zwaal, R F, van Deenen, L L, Roelofsen, B
Format: Artigo
Jezik:Inglês
Izdano: 1985
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC423425/
https://ncbi.nlm.nih.gov/pubmed/3965502
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